Genome Modulation and Editing Selection Guide
Which genome editing technology is right for you?
|Transient knockdown of multiple transcripts||Transient knockdown with low off-target effects||Targeted integration of genetic material into specific integration sites||Stable integration of your gene of interest||Rapid and efficient editing with multiplexing capabilities||Precise and flexible editing; targeting to any gene in any cell|
|Learn more||Learn more||Learn more||Learn more||Learn more||Learn more|
|Ambion® miRNA mimics and inhibitors||RNAi||Jump-In™ Targeted Integration Kits||Flp-In™ System||GeneArt® CRISPR Nuclease Vector||GeneArt® Precision TALs|
|Modification options||Down-regulation (knockdown)||Down-regulation (knockdown)||Integration (knock-in)||Integration (knock-in)||
|Ease of use||Pre-designed constructs available for transfection in cell culture||Pre-designed constructs available for transfection in cell culture||Low effort in vector construction, transfection and clone identification||Low effort in vector construction, transfection and clone identification||Simple and fast design process||Difficult to design (except when using the GeneArt® Precision TALs online design tool)|
|Type of recognition||RNA-RNA||RNA-RNA||DNA-DNA||DNA-DNA||RNA-DNA||Protein-DNA|
|Limitations||Only for transient inhibition of translation||Only for mRNA cleavage; degradation of mRNA is transient||Only for integrations||Only for integrations||Off-target effects||
For Research Use Only. Not for use in diagnostic procedures.