Immune Response Biomarker Profiling (IRBP)
Uncover novel autoantibody markers for cancer, autoimmune disorders, and other diseases at an unprecedented pace with ProtoArray® Human Protein Microarrays. Our Immune Response Biomarker Profiling application was developed on our advanced ProtoArray® Technology, which contains more than 9,000 full-length proteins purified under native conditions.
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Advantages of biomarker discovery using ProtoArray® technology
This high-content discovery tool provides sensitive and reproducible results, quickly and easily (Figure 1). Only ProtoArray® microarrays provide immediate protein identification and involve:
- As little as 10 microliters of sera or plasma
- No pre-labeling or tagging
- Simple profiling protocol for biomarker discovery
ProtoArray® Human Protein Microarrays have been successfully used to identify biomarkers from a number of different diseases. Examples included identifying cancer biomarkers for ovarian , prostate , bladder , and lung cancers . The arrays have also been successfully used to identify non-HLA protein biomarkers in transplantation patients [5-7].
The ProtoArray® Immune Response Biomarker Profiling application is available either as a custom service or as a product.
- Gunawardana CG et al. (2009) Identifying novel autoantibody signatures in ovarian cancer using high-density protein microarrays Clin Biochem 42: 426–429.
- Nguyen MC et al. (2010) Antibody responses to galectin-8, TARP and TRAP1 in prostate cancer patients treated with a GM-CSF-secreting cellular immunotherapy Cancer Immunol Immunother 59:1313-1323.
- Orenes-Piñero E et al. (2010) Serum and Tissue Profiling in Bladder Cancer Combining Protein and Tissue Arrays. J Proteome Res 9: 164-173.
- Gnjatic S et al. (2009) Seromic analysis of antibody responses in non-small cell lung cancer patients and healthy donors using conformational protein arrays J Immunol Methods 341: 50–58.
- Porcheray F et al. (2010) Chronic Humoral Rejection of Human Kidney Allografts Associates With Broad Autoantibody Responses Transplantation 89: 1239-1246.
- Wadia PP et al. (2010) Antibodies specifically target AML antigen NuSAP1 after allogeneic bone marrow transplantation Blood 115: 2077-2087.
- Li L et al. (2009) Identifying compartment-specific non-HLA targets after renal transplantation by integrating transcriptome and “antibodyome” measures Proc Natl Acad Sci USA 106: 4148–4153.
- Pre-service consultation—receive a consultation session with our experienced service scientists to optimize your experimental design
- Post-service comprehensive report—a complete report detailing the profiling experiment, results, and population statistics will be delivered to you in approximately 4 weeks
- Technical support—our responsive support and dedicated staff will be available to you through the completion of your project
Learn more about our Immune Response Biomarker Profiling Service with ProtoArray® v5.0.
For Research Use Only. Not for use in diagnostic procedures.