Antibodies Other Ligands
Figure 1.  Antibodies or other ligands can be coupled onto the beads for affinity protein capture.

A Wide Range of Products - Flexibility for Your Research

Surface-activated Dynabeads® are available in different sizes, with a hydrophobic or hydrophilic nature, and with a variety of surface chemistries (see Table 1 below). To obtain the best possible results it is important to choose a size and surface of the Dynabeads® suited for your application. The choice will depend on the nature of the ligand. In most applications several Dynabeads® products can be used.

Table 1 - Choose the right surface-activated Dynabeads® for your application

Ligand Target Dynabeads® Tosyl-
Dynabeads® Amine Dynabeads® Epoxy Dynabeads® Subcellular
AntibodyLow MW antigen1 or peptide 
Protein or antibody
Protein complex




Antibody FragmentPhage1 or antibody
ProteinPhage or carbohydrate
Nucleic acid
PeptidePhage1 or antibody

Low MV antigen Antibody
Nucleic acids, oligonucleotide, aptamer, PNANucleic acid binding proteins1 4

DNA1, RNA1 or PCR amplicons1

EnymeSubstrate or target for enzyme degradation
Organic chemistry derivatization, including introduction of new functional groups

- Best product choice for listed ligand and target.
- Alternative choice for listed ligand and target.
- Can be used for listed ligand and target.
1 - Dynabeads® pre-coupled with streptavidin may be the best product choice.
2 - Dynabeads® M-450 Epoxy.
3 - Dynabeads® M-450 are recommended for isolation, stimulation, and expansion of cells.
4 - Dynabeads® Amine is modified with an appropriate bifunctional crosslinker prior to immobilization of oligonucleotides.