Silencer® Select siRNAs from Ambion®
- Incorporate the latest improvements in siRNA design, off-target effect prediction algorithms, and chemistry
- Provide unrivalled silencing consistency, potency, and specificity
- Result in fewer failed experiments due to poor silencing
- Yield cleaner, more consistent phenotypic data
Why are Silencer Select siRNAs the Best siRNAs?
- Cleaner, more consistent data
- Design algorithm improves effective siRNA prediction accuracy >25%
- Up to 100 fold more potent than first & second generation siRNA designs
- More consistently yield silenced phenotypes
- Improved specificity of Silencer® Select siRNAs
- Chemical modifications enhance guide strand bias
- Reduced off-target effects by up to 90%
100% Guarantee – The BEST in the Industry
Life Technologies guarantees that when you purchase two Silencer Select Pre-designed siRNA to the same target, then those two siRNAs will silence the target mRNA by 70% or more. To qualify for the guarantee, siRNA's must have been transfected at ≥5 nM and mRNA levels detected 48h post transfection. Real-Time RT-PCR is recommended but not required for this application. Customers must also show > 80% knockdown with a positive control siRNA to demonstrate transfection efficiency. If the guaranteed level of knockdown is not observed and an appropriate positive control is successful, a onetime replacement of up to two new Silencer Select siRNA designs will be provided free of charge. This guarantee does not extend to any replacement product.
PRODUCT REPLACEMENT AS SET FORTH ABOVE IS LIFE TECHNOLOGIES’ SOLE OBLIGATION AND CUSTOMER’S SOLE AND EXCLUSIVE REMEDY WITH RESPECT TO THE GUARANTEE GIVEN ABOVE. To arrange a replacement, contact Technical Services. Please be ready to supply data indicating transfection efficiency and measurement of mRNA knockdown. Contact Technical Support if you require such a replacement.