INGENUITY® VARIANT
ANALYSIS™ MODULE

Identify variants from human sequencing data in just hours


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Quickly identify biologically relevant variants

The Ingenuity® Variant Analysis™ module combines analytical tools and integrated content to help you rapidly identify the most compelling variants, in real time, using selection criteria based upon both published biological evidence and your own knowledge of disease research biology.

1 Design Custom Panel

Ion AmpliSeq™ Designer

2 Run Sequence

Ion Proton™ & Ion PGM™ Sequencers

3 Analyze Data

Ion Reporter™ Software

4 Compare

Single/Trio Samples

5 Annotate

Ingenuity® Variant Analysis

6 Report

Interpretive Report

 

How does the Ingenuity® Variant Analysis™ module work?

The Ingenuity® Variant Analysis™ module is integrated into Ion Reporter™ Software, providing variant annotation via simple and secure access to the same robust data security standards as described in the HIPAA rules, in a web-based application without logging in again or manually uploading files.


Interactive filtering to rapidly prioritize variants in genetic disease

The Ingenuity® Variant Analysis™ module uses a series of filters that you can apply to quickly exclude common variants (based on 1000 Genomes project) and non-deleterious variants, and then relate variants to relevant biology. You can easily ask biological questions to identify variants that impact symptoms, pathways, processes, or genes implicated in genetic disease progression or drug responses.


•    Quickly identify biologically relevant variants—focus on important variants via biological context, genetic, cancer driver, and pharmacogenetic filters

•    Interactive, customizable application—see visualizations, such as pathway diagrams, of the potential impact of each variant

•    Evidence-backed insights—leverage over 4 million literature findings from the Ingenuity® Knowledge Base

The Ingenuity® Knowledge Base

The biological filtering in Ingenuity® Variant Analysis™ Software is made possible by the rich biological content in the Ingenuity® Knowledge Base, plus additional sources of variant-level content.  

The Ingenuity® Knowledge Base is a repository of expertly curated biological interactions and functional annotations created from millions of individually modeled relationships between proteins, genes, complexes, cells, tissues, drugs, and diseases. These modeled relationships, or findings, include rich details and links to original articles, all reviewed for accuracy by PhD-level scientists.

The curated content in the Ingenuity® Knowledge Base is structured into an ontology that allows for contextual information, computation by application, and synonym resolution to ensure consistency across concepts.

 

 

*Renewal includes access to software updates

For Research Use Only. Not for use in diagnostic procedures.