Our Synthetic Biology Services cover the complete workflow from strain characterization to host engineering, including pathway optimization, synthetic circuit design, and next-generation cloning techniques. This offering combines Life Technologies leading Ion Torrent and SOLiD® next-generation sequencing platforms with bioinformatics support ranging from next-generation sequencing analysis to metabolic model development analysis. Traditional bioinformatics solutions, such as the Vector NTI® software suite, advanced cloning and assembly technologies, and genome editing tools and host systems are also available. Our scientific specialists from each area will work together to create a tailored project plan to match your needs.

Choose Life Technologies as your partner to:

  • Characterize your host strain by sequencing the host genome and/or transcriptome, taking metabolic measurements, and analyzing downstream data.
  • Develop a metabolic model combining gene expression profiles and metabolome analysis for your host of interest, to rationally design your pathway engineering strategy.
  • Design optimized pathways through the use of synthetic biology engineering approaches.
  • Construct your pathways or vectors using the fastest and most suitable cloning technology.
  • Engineer your host using Life Technologies DNA delivery and genome engineering expertise.

Additional References

  1. Clancy, KP. Use of genome-scale metabolic reconstruction coupled with characterized parts to enable synthetic engineering of organisms. Paper presented at the 20th Annual International Conference on Intelligent Systems for Molecular Biology, July 15–17, 2012, Long Beach, CA, USA.
  2. Clancy, KP, et al. De novo assembly of a novel filamentous blue green algal genome for leptolyngbya sp. strain BL0902 enabled by a novel, extra-long read sequencing protocol. Poster presented at the 20th Annual International Plant and Animal Genome Conference, January 14–18, 2012, San Diego, CA, USA.