In this synthetic biology webinars module, our scientists and collaborators will cover cell engineering in particular technologies, techniques, and applications. The webinars are designed to give a basic framework for learning these technologies. Each webinar also provides background information, data analysis, and helpful tips from our experienced technical support scientists and collaborators.

Recorded Cell Engineering & Genome Editing webinars

Basics of Detection & Analysis

Understanding the workflow and probing the efficiency and consequences of gene editing are crucial for successful precision genome manipulation. This webinar is designed for researchers just getting started with genome editing, and others who want to learn the essentials of how to design detection and analysis experiments. Listen to this on-demand webinar to learn effective strategies for detection and analysis of genomic modification induced by engineered nucleases.

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Basics of Design: Knockout and Knock-in Design Using TAL Effectors and CRISPRs

Does your work involve disease models? Do you need to introduce specific genomic changes in the cells of your choice? Do you want to knock out or knock in a gene in your model cells? If the answer to any of these questions is yes, this is a must-see webinar. The last few years have seen dramatic technical leaps in the ability to precisely manipulate the mammalian genome. Development of precision genome editing tools like TAL (transcription activator-like) effector nucleases and CRISPR (clustered regularly interspaced palindromic repeat) systems has enabled the specific introduction of targeted DNA double-strand breaks. Cellular machinery primarily repairs these breaks via the nonhomologous end-joining pathway, which can introduce small insertions or deletions at the break site (thereby causing a disruption). Both TAL effectors and CRISPR systems have been used to generate gene disruptions, perform SNP corrections, and direct gene insertions.

Attend this webinar to learn about common strategies for achieving these goals, including designing the editing tool and donor DNAs using our TAL and CRISPR technologies.

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NEW Editing tool targeting any DNA sequence

Transcription activator-like (TAL) effector proteins provide custom DNA-binding domains for accurate DNA targeting and precise genome editing. A limitation of traditional TAL methods is that they require a 5’ T at the beginning of their binding sequences. Recently, however, a more powerful TAL tool was developed that allows scientists to target any sequence in the genome. GeneArt® PerfectMatch TALs leverage this new technology and can be designed to target any locus in the genome. Data and results show efficient cleavage with both RNA and DNA formats.  Join us for this new webinar focused on the latest advancements on TAL technology.

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GeneArt® Elements™ vector construction and combinatorial parts assembly

You’re invited to join our synthetic biology webinar “GeneArt® Elements™: a combination of standardized genetic parts and customer parts for the cost-effective construction of individualized vectors, pathways, and more.”

In this webinar Dr. Michael Liss, manager of Molecular Biology Research and Development at Thermo Fisher Scientific, discusses GeneArt® Elements™ vector construction and combinatorial parts assembly. The GeneArt® Elements™ collection offers access to a large set of well-characterized genetic parts that can be used for different purposes, with easy online design and ordering. The ability to cost-efficiently test different promoters, terminators, or other functional elements helps ensure the best possible outcomes for further downstream applications.

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CRISPR-Cas9 for large-scale cell engineering

Recent advancements in molecular and cell biology have provided researchers with simple yet powerful genome editing tools like the CRISPR/Cas9 system, making it relatively easy to target and regulate user-defined endogenous genes in a sequence-specific manner. In this webinar, you’ll discover formats and workflows for successful CRISPR/Cas9 genome editing, how to edit multiple loci or alleles simultaneously, how to use the CRISPR/Cas9 system for in vivo applications and more.

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RNAi technology reveals possible targets for treating Parkinson's disease

Gene silencing through RNA interference (RNAi) has revolutionized our ability to interrogate gene function. This webinar showcases a study to highlight considerations for running large-scale RNAi screens, ranging from the basic concepts and experimental setup to computational and experimental approaches used to overcome the prevalence of off-target effects.

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An introduction to RNA-guided genome editing with CRISPR

Genome editing technique involves the use of engineered nucleases in conjunction with endogenous repair mechanisms to insert, delete, or replace a specific DNA sequence from a desired location in the genome. Recently, the Type II CRISPR/Cas bacterial adaptive immune system from Streptococcus pyogenes has been engineered and demonstrated to function as an effective gene-editing tool in various eukaryotic genomes, including mammalian. This webinar provides an overview on CRISPR/Cas9-mediated genome editing.

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Genome editing of iPSCs from Parkinson’s disease patients using TAL technology

In this webinar we examine genetic engineering of iPSCs derived from Parkinson’s disease patient samples, which provide model systems to study disease mechanisms in cell types not previously available. Next-generation tools for stem cell engineering, GeneArt® Precision TALs, offer an extremely efficient method for targeting and regulating expression at defined sequences within the genome.

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An introduction to precise genome editing with TAL effectors

Transcription activator–like (TAL) effectors are proteins expressed by plant bacterial pathogens to evade host defense mechanisms. Due to the unique and predictable code for each DNA base within the amino acid repeat regions, TAL DNA-binding domains can be custom tailored to bind any DNA sequence of choice. Designer TAL effectors are attractive tools for genome- and cell-engineering applications. This webinar is an introduction to designer TAL effectors and their applications for targeted gene editing.

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Synthetic TAL effectors for targeted gene activation in plants

The ability to selectively activate or inhibit gene expression has value in basic plant biology and agriculture. Targeted gene activation can be achieved by specifically expressing a gene of interest in a temporally and/or spatially defined manner in transgenic plants, or by directly activating endogenous gene expression in its original genetic context. Join this webinar where Dr. Neal Stewart, professor and director at the Tennessee Plant Research Center, provides novel insights into the potential applications of synthetic TALEs for targeted gene activation of transgenes in plants.

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An introduction to plant genetic engineering

This webinar introduces the newest genome-editing technology for plants, GeneArt® Precision TALs. The scientific presentation also covers other cloning and algae engineering technologies, such as Gateway® and GeneArt® gene synthesis, to support your quest to engineer the next generation of crops.

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Check out our plant sciences webinar series, dedicated to providing tools and technologies that will lead to remarkable agricultural discoveries.

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