Cell-Based Assay Development
Assays to Fit Your Research Needs
With a broad array of assay technologies available across Life Technologies, our Custom Biology Services team can recommend a technology to best suit your unique requirements. An overview of these technologies can be found below.
|BacMam-enabled Cellular Assays||An efficient, easy-to-optimize, and robust method for interrogating specific signal transduction events in the cell background of your choice.||
|GeneBLAzer® Reporter Gene Assays||The GeneBLAzer® technology utilizes a fluorescence resonance energy transfer (FRET)-based, ratiometric detection method that reduces experimental noise, which can lead to false hits.||
This technology is readily accessible for studying numerous target classes and cellular processes.
|Tango™ Assay System||The Tango™ assay system provides a readout that is specific to the target receptor which ensures a selective readout. False positives are minimized because the readout is proximal to the actual site of receptor activation. Assay is independent of the G protein the receptor signals through which enables study of any GPCR (including orphans).||This technology is ideal for GPCRs; however, the same techniques can apply to other cellular protein-protein interactions.|
|LanthaScreen® Cellular Assay System||Study posttranslational modifications in a physiologically relevant cellular context. With this assay format you can quickly screen with a simple and homogeneous high-throughput screening (HTS). Amenable assay format
Interrogates the effects of your compounds on specific signaling events within a pathway. Analyze multiple post-translational modifications using physiological pathway kinetics.
|This technology is designed to address specific interactions within signaling pathways.|
|CellSensor® Cell Lines||Transcriptional reporter gene assay for high-throughput screening and profiling||These cell lines are ideal for analysis of an entire signal transduction pathway with a single endpoint readout.|
|Jump-In™ technology||Allows integration and expression of your gene of interest in mammalian cells at a specific genomic location. Isogenic stable cell line generation within 2–3 weeks. Ideal for studying orthologs or various genetic mutations rapidly without concern about positional effects.||This technology is universally applicable for any mammalian cell line engineering project.|
Custom Biology Services Team
|With many labs facing resources restraints, our Custom Biology team offers institutions a powerful resource to extend their research teams. Wholly dedicated to developing custom tools and assays, the team has the expertise to select an assay technology from the extensive Life Technologies toolbox and use these technologies to craft tools that meet your unique requirements.|
Dedicated Project Management
From your initial inquiry through every milestone of your project, you can expect exceptional service and frequent, proactive communication from a dedicated project manager. Your project manager will help ensure all parties involved in the project are aligned on project requirements, timelines and budgets.
For Research Use Only. Not for use in diagnostic procedures.