Strength in Numbers - Drug Discovery Services
Listen to the SelectScreen® team describe
how they deliver reliable profiling data on rapid timelines.
    

Expect and receive high quality kinase profiling data in days and accelerate your lead discovery projects with SelectScreen® Kinase Profiling Services from Life Technologies.

Labs from pharmaceutical, biotech, consumer goods, and academic institutions have utilized SelectScreen® Kinase Profiling Service since their initiation in 2004.

Our kinase panel has just expanded! Over 400 kinase assays now available for screening and profiling. See the Broad Assay Panel tab below for the full listing.

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The fastest kinase profiling service just got faster

The new Accelerated Data Delivery™ service returns up to 80% of your kinase profiling data to you in as little as 48 hours

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Customer Testimonials

Why do scientists trust the SelectScreen® Services team?

  • Average data delivery time of just 3.8 days - so you can get data to your medicinal chemists more quickly
  • Access data in real-time – as soon as it is available – via our secure online portal
  • Broad panel of more than 400 purified kinases – to help you establish how selective a compound is to its intended targets
  • State-of-the-art compound management system ensures consistently high quality data is delivered for every project
  • SelectScreen® labs based in the US and the UK provide profiling services for customers worldwide
  • Complete Lab Information Management System (LIMS) ensures project traceability and consistency

Project Options

Customize your kinase profiling project to get the right data for your research.

Standard service options include:

  • Targets – >400 available biochemical assays
  • Mode – Single point concentrations and IC50 and/or EC50 determinations
  • Choice of ATP concentration – 10µM, 100µM, and Km [app] ATP (activity assays only)

For the kinases that are available in our activity assays, comprehensive titrations are performed against the Life Technologies panel of available substrates.  In addition, ATP titrations are performed for each of these kinases to determine the Km[app] ATP for each target.  As a result, you can choose to have your compound run at, above, or below the Km[app] ATP for each kinase within the panel that utilizes an activity assay.  This flexibility allows you to identify specific types of inhibitors with various mechanisms of action.

To discuss your kinase profiling project requirements, send us an inquiry or email us.

Personalized Support

From project beginning to end, you can rely on our Drug Discovery Services project management team to provide frequent project communication via a single point of contact.

Watch this two-minute video to see how our project managers and technical specialists create an exceptional experience for our customers.

If you have already received a quote number, place an order here.


Footnotes:
– Source: HTStec report, 2011

Technology Overview

Currently, two different assay platforms are available for profiling – activity and binding. The Z’-LYTE® and Adapta®  kinase activity assays are used most extensively for profiling and a smaller subset of kinases may be profiled using our LanthaScreen® Eu Kinase Binding Assays.

Overview of available formats

Z'LYTE® Technology Overview Protocol and Assay Conditions
Adapta® Technology Overview Protocol and Assay Conditions
LanthaScreen® Eu Kinase Binding Assay  Technology Overview Protocol and Assay Conditions

 A stringent validation process ensures the highest quality data possible with each data point performed in duplicate.  Strict quality control protocols ensure that any assay results not meeting set specifications will be automatically repeated, this includes a control inhibitor titration (IC50) for each kinase on every plate.

To discuss your kinase profiling project requirements, send us an inquiry or email us

Broad Assay Panel

Kinase
Activity Assays
Binding Assay
 
Z′-LYTE®
Adapta®
LanthaScreen®
ABL1
   
ABL1 E255K
   
ABL1 G250E
   
ABL1 H396P    
ABL1 M351T    
ABL1 Q252H    
ABL1 T315I
   
ABL1 Y253F
   
ABL2 (Arg)
   
ACVR1 (ALK2)    
ACVR1 (ALK2) R206H    
ACVR1B (ALK4)
   
ACVR2A    
ACVR2B    
ACVRL1    
ADRBK1 (GRK2)
   
ADRBK2 (GRK3)
   
AKT1 (PKB alpha)
   
AKT2 (PKB beta)
   
AKT3 (PKB gamma)
   
ALK    
ALK C1156Y    
ALK F1174L    
ALK L1196M    
ALK R1275Q    
AMPK (A1/B1/G2)    
AMPK (A1/B1/G3)    
AMPK (A1/B2/G1)    
AMPK (A2/B2/G1)    
AMPK (A2/B2/G2)    
AMPK A1/B1/G1
   
AMPK A2/B1/G1
   
AURKA (Aurora A)
   
AURKB (Aurora B)
   
AURKC (Aurora C)
   
AXL
   
AXL R499C    
BLK
   
BMPR1A (ALK3)    
BMPR1B (ALK6)    
BMPR2    
BMX
   
BRAF
 
BRAF V599E
 
BRSK1 (SAD1)
   
BRSK2    
BTK
   
CAMK1 (CaMK1)  
 
CAMK1D (CaMKI delta)
   
CAMK2A (CaMKII alpha)
   
CAMK2B (CaMKII beta)
   
CAMK2D (CaMKII delta)
   
CAMK2G (CaMKII gamma)    
CAMK4 (CaMKIV)
   
CAMKK1 (CAMKKA)    
CAMKK2 (CaMKK beta)    
CASK    
CDC42 BPA (MRCKA)
   
CDC42 BPB (MRCKB)
   
CDC7/DBF4    
CDK1/cyclin A2    
CDK1/cyclin B
   
CDK11 (Inactive)    
CDK14 (PFTK1)/cyclin Y    
CDK16 (PCTK1)/cyclin Y    
CDK2/cyclin A
   
CDK2/cyclin A1    
CDK2/cyclin A2    
CDK2/cyclin E1    
CDK2/cyclin O    
CDK3/cyclin E1    
CDK5 (Inactive)    
CDK5/p25
   
CDK5/p35
   
CDK7/cyclin H/MNAT1  
 
CDK8/cyclin C    
CDK9 (Inactive)    
CDK9/cyclin K    
CDK9/cyclin T1  
 
CHEK1 (CHK1)
   
CHEK2 (CHK2)
   
CHUK (IKK alpha)  
 
CLK1
   
CLK2
   
CLK3
   
CLK4    
CSF1R (FMS)
   
CSK
   
CSNK1A1 (CK1 alpha 1)
   
CSNK1D (CK1 delta)
   
CSNK1E (CK1 epsilon)
   
CSNK1G1 (CK1 gamma 1)
   
CSNK1G2 (CK1 gamma 2)
   
CSNK1G3 (CK1 gamma 3)
   
CSNK2A1 (CK2 alpha 1)
   
CSNK2A2 (CK2 alpha 2)
   
DAPK1  
 
DAPK2    
DAPK3 (ZIPK)
   
DCAMKL2 (DCK2)
   
DDR1    
DDR2    
DDR2 N456S    
DDR2 T654M    
DMPK    
DNA-PK
   
DYRK1A
   
DYRK1B
   
DYRK2    
DYRK3
   
DYRK4
   
EEF2K
   
EGFR (ErbB1)
   
EGFR (ErbB1) L858R
   
EGFR (ErbB1) L861Q
   
EGFR (ErbB1) T790M
   
EGFR (ErbB1) T790M L858R
   
EGFR d746-750    
EIF2AK2    
EPHA1
   
EPHA2
   
EPHA3    
EPHA4
   
EPHA5
   
EPHA6    
EPHA7    
EPHA8
   
EPHB1
   
EPHB2
   
EPHB3
   
EPHB4
   
ERBB2 (HER2)
   
ERBB4 (HER4)
   
FER
   
FES (FPS)
   
FGFR1
   
FGFR1 V561M    
FGFR2
   
FGFR3
   
FGFR3 G697C    
FGFR3 K650E
   
FGFR3 K650M    
FGFR4
   
FGR
   
FLTA (VEGFR3)    
FLT1 (VEGFR1)
   
FLT3
   
FLT3 D835Y
   
FLT3 ITD    
FRAP1 (mTOR)
   
FRK (PTK5)
   
FYN
   
FYN A    
GRK1    
GRK4
   
GRK5
   
GRK6
   
GRK7
   
GSG2 (Haspin)  
 
GSK3A (GSK3 alpha)
   
GSK3B (GSK3 beta)
   
HCK
 
 
HIPK1 (Myak)
   
HIPK2
   
HIPK3 (YAK1)
   
HIPK4
   
ICK    
IGF1R
   
IKBKB (IKK beta)
   
IKBKE (IKK epsilon)
   
INSR
   
INSRR (IRR)
   
IRAK1  
 
IRAK4
   
ITK
   
JAK1
   
JAK2
   
JAK2 JH1 JH2
   
JAK2 JH1 JH2 V617F
   
JAK3
   
KDR (VEGFR2)
   
KIT
   
KIT A829P    
KIT D816H    
KIT D816V    
KIT D820E    
KIT N822K    
KIT T670E    
KIT T670I
   
KIT V559D T670I    
KIT V654A    
KIT Y823D    
LATS1    
LATS2    
LCK    
LIMK1    
LIMK2    
LRRK2  
 
LRRK2 FL    
LRRK2 G2019S  
 
LRRK2 G2019S FL    
LRRK2 I2020T   
 
LRRK2 R1441C   
 
LTK (TYK1)
   
LYN A
   
LYN B
   
MAP2K1 (MEK1 )
 
MAP2K1 (MEK1) S218D S222D    
MAP2K2 (MEK2)
 
MAP2K3 (MEK3)    
MAP2K6 (MKK6)
 
MAP2K6 (MKK6) S207E T211E    
MAP3K10 (MLK2)    
MAP3K11 (MLK3)    
MAP3K14 (NIK)    
MAP3K2 (MEKK2)    
MAP3K3 (MEKK3)    
MAP3K5 (ASK1)    
MAP3K7/MAP3K7IP1 (TAK1-TAB1)    
MAP3K8 (COT)
   
MAP3K9 (MLK1)
   
MAP4K1 (HPK1)    
MAP4K2 (GCK)
   
MAP4K3 (GLK)    
MAP4K4 (HGK)
   
MAP4K5 (KHS1)
   
MAPK1 (ERK2)
   
MAPK10 (JNK3)
 
MAPK11 (p38 beta)
   
MAPK12 (p38 gamma)
   
MAPK13 (p38 delta)
   
MAPK14 (p38 alpha)
   
MAPK14 (p38 alpha) Direct
   
MAPK15 (ERK7)    
MAPK3 (ERK1)
   
MAPK8 (JNK1 )
 
MAPK9 (JNK2)
 
MAPKAPK2
   
MAPKAPK3
   
MAPKAPK5 (PRAK)
   
MARK1 (MARK)
   
MARK2
   
MARK3
   
MARK4
   
MATK (HYL)
   
MELK
   
MERTK (cMER)
   
MERTK (cMER) A708S    
MET (cMet)
   
MET D1228H    
MET M1250T
   
MINK1
   
MKNK1 (MNK1)
   
MKNK2 (MNK2)    
MLCK (MLCK2)    
MST1R (RON)
   
MST4
   
MUSK
   
MYLK (MLCK)    
MYLK2 (skMLCK)
   
MYO3B (MYO3 beta)    
NEK1
   
NEK2
   
NEK4
   
NEK6
   
NEK7
   
NEK9
   
NLK    
NTRK1 (TRKA)
   
NTRK2 (TRKB)
   
NTRK3 (TRKC)
   
NUAK1 (ARK5)  
 
NUAK2    
PAK1
   
PAK2 (PAK65)
   
PAK3
   
PAK4
   
PAK6
   
PAK7 (KIAA1264)
   
PASK
   
PDGFRA (PDGFR alpha)
   
PDGFRA D842V
   
PDGFRA T674I
   
PDGFRA V561D
   
PDGFRB (PDGFR beta)
   
PDK1
   
PDK1 Direct
   
PHKG1
   
PHKG2
   
PI4KA  
 
PI4KB (PI4K beta)  
 
PIK3C2A (PI3K-C2 alpha)  
 
PIK3C2B (PI3K-C2 beta)  
 
PIK3C3 (hVPS34)  
 
PIK3CA/PIK3R1 (p110 alpha/p85 alpha)  
 
PIK3CD/PIK3R1 (p110 delta/p85 alpha)  
 
PIK3CG (p110 gamma)    
PIM1
   
PIM2
   
PKN1 (PRK1)
   
PKN2    
PLK1
   
PLK2
   
PLK3
   
PLK4    
PRKACA (PKA)
   
PRKACB (PRKAC beta)    
PRKACG (PRKAC gamma)    
PRKCA (PKC alpha)
   
PRKCB1 (PKC beta I)
   
PRKCB2 (PKC beta II)
   
PRKCD (PKC delta)
   
PRKCE (PKC epsilon)
   
PRKCG (PKC gamma)
   
PRKCH (PKC eta)
   
PRKCI (PKC iota)
   
PRKCN (PKD3)
   
PRKCQ (PKC theta)
   
PRKCZ (PKC zeta)
   
PRKD1 (PKC mu)
   
PRKD2 (PKD2)
   
PRKG1
   
PRKG2 (PKG2)
   
PRKX
   
PTK2 (FAK)
   
PTK2B (FAK2)
   
PTK6 (Brk)
   
RAF1 (cRAF) Y340D Y341D
 
RET
   
RET G691S    
RET M918T    
RET V804L
   
RET V804M    
RET Y791F
   
RIPK2    
RIPK3    
ROCK1
   
ROCK2
   
ROS1
   
RPS6KA1 (RSK1)
   
RPS6KA2 (RSK3)
   
RPS6KA3 (RSK2)
   
RPS6KA4 (MSK2)
   
RPS6KA5 (MSK1)
   
RPS6KA6 (RSK4)
   
RPS6KB1 (p70S6K)
   
SGK (SGK1)
   
SGK2
   
SGKL (SGK3)
   
SIK1    
SIK3    
SLK    
SNF1LK2
   
SPHK1    
SPHK2    
SRC
   
SRC N1
   
SRMS (Srm)
   
SRPK1
   
SRPK2
   
STK16 (PKL12)    
STK17A (DRAK1)    
STK17B (DRAK2)    
STK22B (TSSK2)
   
STK22D (TSSK1)
   
STK23 (MSSK1)
   
STK24 (MST3)
   
STK25 (YSK1)
   
STK3 (MST2 )
   
STK32B (YANK2)    
STK32C (YANK3)    
STK33    
STK38 (NDR)    
STK38L (NDR2)    
STK39 (STLK3)    
STK4 (MST1)
   
SYK
   
TAOK1    
TAOK2 (TAO1)
   
TAOK3 (JIK)    
TBK1
   
TEC    
TEK (Tie2)
   
TEK (TIE2) R849W    
TEK (TIE2) Y1108F    
TESK2    
TGFBR1 (ALK5)    
TGFBR2    
TLK1    
TLK2    
TNIK    
TNK2 (ACK)    
TTK    
TXK
   
TYK2
   
TYRO3 (RSE)
   
ULK1    
ULK2    
ULK3    
WEE1    
WNK2    
WNK3    
YES1
   
ZAK    
ZAP70
   

Kinase Biology Tools

With the broadest collections of assays, high-throughput screening and profiling services, and access to customized assays and tools designed to meet your specifications, your lab can choose the right kinase biology tools and services for your exact stage of research.

For Research Use Only. Not for use in diagnostic procedures.