showcase.par.22027.image.0.0.1

Accelerate your process for identifying your most promising drug compounds, and enable your medicinal chemists to receive data faster with our cost-effective lead optimization services.

Send us an inquiry

SelectScreen® Lead Optimization Services offer drug discovery researchers a faster method for narrowing the selection of drug candidates for downstream selectivity profiling and further investigation.

Our in-house team can run biochemical and cellular assays to optimize drug potency and generate dose-response curves, identifying the compounds that cause the desired effect in your target of interest. Choose from our broad portfolio of assay technologies, or provide your own targets/assays and we can perform validation.

Data Delivery in Days

Lead optimization services offer an advantage over broader screening because they can deliver data quickly, typically in 3 to 5 days (depending on the assay), and at lower cost than large panel screens. This enables you to make chemistry decisions more rapidly and move leads forward.

  Broad profiling Lead optimization
Number of targets/assays Many Few
Mode Single point with dose-response curve follow-up Dose-response curves
Submission schedule On demand Weekly schedule
Client commitment On demand 6+ months
Turnaround time Avg. 4 to 8 days Avg. 2 to 5 days
Cost $$ $

After leads are optimized, top drug candidates can be carried forward for selectivity profiling to determine specificity and downstream impact in preparation for possible future clinical testing.

To discuss your lead optimization program needs with us, send us an inquiry.

Personalized Support

From project beginning to end, you can rely on our Drug Discovery Services project management team to provide frequent project communication via a single point of contact.

Watch this two-minute video to see how our project managers and technical specialists create an exceptional experience for our customers.

If you have already received a quote number, place an order here.