Table 10.2 Rhodamine 110–based bis-peptide substrates.

Cat. No. Proteinase Substrate * Enzymes †
R22122(Asp)2-R110caspase-3 and other apoptosis-related proteases ref
R6506(CBZ-Ala-Ala-Ala-Ala)2-R110elastase ref
R33752(CBZ-Ala-Ala-Asp)2-R110granzyme B
R6508(CBZ-Ala-Arg)2-R110trypsin ref
R6501(CBZ-Arg)2-R110trypsin ref
R22120(CBZ-Asp-Glu-Val-Asp)2-R110caspase-3, -6, -7, -8, -10 ref
R6505(CBZ-Ile-Pro-Arg)2-R110trypsin ref
R22125
R22126
(CBZ-Ile-Glu-Thr-Asp)2-R110caspase-8
R33753(CBZ-Leu-Glu-Glu-Asp)2-R110caspase-13
R6502(CBZ-Phe-Arg)2-R110plasmin, cathepsin L ref
R33750(CBZ-Tyr-Val-Ala-Asp)2-R110caspase-1, -4
R33755(CBZ-Val-Asp-Val-Ala-Asp)2-R110caspase-2
R33754(CBZ-Val-Glu-Ile-Asp)2-R110caspase-6
R22124(p-tosyl-Gly-Pro-Arg)2-R110thrombin ref
* CBZ = benzyloxycarbonyl; R110 = rhodamine 110; SC = succinoyl; p-tosyl = p-toluenesulfonyl. † Caspase substrates can often be cleaved by multiple enzymes. The caspase most often associated with the given peptide sequence is listed first.
For Research Use Only. Not for use in diagnostic procedures.