BRAF [V599E] Recombinant Human Protein

See all Serine⁄Threonine Kinases

Catalog # Unit Size List Price
PV4173 1 mg 5400.00

Description

BRAF acts upstream of MEK in the MAP kinase pathway and is involved in cell division, differentiation, and secretion. The BRAF mutant V599E is oncogenic and found in a variety of   View full product details >

General Specifications

Form
Frozen
Species
Human
Gene Aliases
BRAF V599E
Kinase Group
Ser⁄Thr Kinases: TKL Group
Product Size
1 mg
Accession Number
NP_004324.1, V599E
Molecular Weight
67.1 kDa
Research Category
Drug Development
Validated Application
Kinase Assay
Protein Tag or Fusion
GST Tag
Expression
Baculovirus
Kinase Family
RAF Kinase Family
Protein Form
Catalytic
Regulatory Statement
For Research Use Only. Not for use in diagnostic procedures.

Product Applications

  • Proteins, Expression, Isolation & Analysis
dda71f818e7b2d3bc7e90605b5682b71_CmgtBuyProduct

BRAF Recombinant Human Protein

See all Serine⁄Threonine Kinases

Catalog # Unit Size List Price
PV3848 10 µg 379.00

Description

BRAF is involved in the transduction of mitogenic signals from the cell membrane to the nucleus. It is activated by somatic point mutation in human cancer, and is thought to play   View full product details >

General Specifications

Gene ID
2353, 673
Species
Human
Target Gene
v-raf murine sarcoma viral oncogene homolog B1
Gene Aliases
BRAF, BRAF1
Kinase Group
Ser⁄Thr Kinases: TKL Group
Product Size
10 µg
Protein Family
Kinases & Inhibitors
Protein Subtype
Serine⁄Threonine Kinases
Accession Number
NP_004324.2
Molecular Weight
113.6 kDa
Research Category
Signal Transduction
Oncology
System Compatibility
Z'-LYTE™
Omnia® Bulk Substrate
LanthaScreen® Substrate
LanthaScreen® Antibody
Validated Application
Kinase Assay
Protein Tag or Fusion
GST Tag
Expression
Baculovirus
Kinase Family
RAF Kinase Family
Protein Form
Recombinant
Full Length
Shipping Condition
Dry Ice
Regulatory Statement
For Research Use Only. Not for use in diagnostic procedures.

Product Applications

  • Drug Discovery & Development
  • Proteins, Expression, Isolation & Analysis
PV3848
5a57922b5a370b7605f5c56c91b37c7d_CmgtBuyProduct

B-Raf Mouse mAb (clone 1C1G6A4)

See all Protein Specific Primary Antibodies

Catalog # Unit Size List Price
375600 100 µg 299.00

Description

Mouse anti-B-Raf; Unconjugated Monoclonal antibody specific to Human, Mouse B-Raf. This antibody is validated for use in Western Blot, Immunoassay (ELISA). Anti-B-Raf recognizes   View full product details >

General Specifications

Reactivity
Human
Mouse
Validated Application
Western Blot
ELISA
Host
Mouse
Clonality
Monoclonal
Clone ID
1C1G6A4
Target Gene
B-Raf
Gene ID
673
Label or Dye
Unconjugated
Purification
Affinity Purified
Product Size
100 µg
Shipping Condition
Wet Ice
Regulatory Statement
For Research Use Only. Not for use in diagnostic procedures.

Product Applications

  • Cell Analysis
  • Drug Discovery & Development
  • Proteins, Expression, Isolation & Analysis
375600
f974ec825a45a63eae00718e0804c2de_CmgtBuyProduct

Yotiao Rabbit Polyclonal Antibody View 2 Citations

See all Protein Specific Primary Antibodies

Catalog # Unit Size List Price
360300 100 µg 299.00

Description

Rabbit anti-Yotiao; Unconjugated Polyclonal antibody specific to Human, Mouse, Rat Yotiao. This antibody is validated for use in Western Blot, Immunoassay (ELISA). Anti-Yotiao   View full product details >

General Specifications

Reactivity
Human
Mouse
Rat
Validated Application
Western Blot
Immunoprecipitation
ELISA
Host
Rabbit
SubClass (Isotype)
IgG
Clonality
Polyclonal
Target Gene
Yotiao
Gene ID
10142
Label or Dye
Unconjugated
Purification
Epitope Affinity Purified
Product Size
100 µg
Shipping Condition
Wet Ice
Regulatory Statement
For Research Use Only. Not for use in diagnostic procedures.

Product Applications

  • Cell Analysis
  • Proteins, Expression, Isolation & Analysis
360300
74d4771e9b005f5fe0c3d45cd1ae4caf_CmgtBuyProduct

CellSensor® AP-1-bla A375 Cell Line

See all Pathway Analysis Cell Based Assay Kits

Catalog # Unit Size List Price
K1660 1 vial 9880.00

Description

The CellSensor® AP1-bla A375 cell line contains a beta-lactamase reporter gene under control of the AP1 response element stably integrated into A375 cells. A375 cells are human   View full product details >

General Specifications

System
CellSensor™
Cell State
Dividing Cells
Product Size
1 vial
Druggable Target
Signaling Pathway
Regulatory Statement
For Research Use Only. Not for use in diagnostic procedures.

Product Applications

  • Drug Discovery & Development
K1660
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LanthaScreen® Tb-pMAP2K1 (pSer217⁄221) Antibody

See all TR-FRET Primary Antibodies

Catalog # Unit Size List Price
PV4817 25 µg 2679.23

Description

A member of the MAP Kinase family, MAP2K1 (mitogen-activated protein kinase kinase 1) is phosphorylated at Ser217⁄221 by a range of MAPK family members including Raf and B-   View full product details >

General Specifications

Readout
End Point
Reactivity
Human
Target Gene
Ser/Thr Kinases
Label or Dye
Tb (Terbium)
Product Size
25 µg
Excitation⁄Emission (nm)
340⁄490, 520
Shipping Condition
Dry Ice
Regulatory Statement
For Research Use Only. Not for use in diagnostic procedures.

Product Applications

  • Drug Discovery & Development
PV4817
650f2d250b63861c3af908a0d0bb986f_CmgtBuyProduct

TaqMan® Mutation Detection Reference Assays

Catalog # Unit Size
4465807 150 µL

Description

TaqMan® Mutation Detection Reference Assays   View full product details >

General Specifications

Shipping Condition
Room Temperature
Product Size
150 µL

Product Applications

  • Gene Expression Analysis & Genotyping
  • PCR & Real-Time PCR
4465807
c952ef0d47f92f6ac6ad8fa134a27bb0_CmgtBuyProduct

TaqMan® EGFR Exon 19 Deletions Assay

Catalog # Unit Size
4465805 150 µL

Description

TaqMan® EGFR Exon 19 Deletions Assay   View full product details >

General Specifications

Shipping Condition
Room Temperature
Product Size
150 µL

Product Applications

  • PCR & Real-Time PCR
4465805
54e0a8b4ca215f4f195ada1a350a11cd_CmgtBuyProduct

TaqMan® Mutation Detection Assays

Catalog # Unit Size
4465804 150 µL

Description

TaqMan® Mutation Detection Assays   View full product details >

General Specifications

Shipping Condition
Room Temperature
Product Size
150 µL

Product Applications

  • Gene Expression Analysis & Genotyping
  • PCR & Real-Time PCR
4465804
aa856e11f1a6a4a59f18d555f66b86fc_CmgtBuyProduct

Ion AmpliSeq™ RNA Cancer Panel

See all Library Preparation Kits for Sequencing

Catalog # Unit Size List Price
4482572 24 reactions 600.00

Description

The Ion AmpliSeq™ RNA Cancer Panel is a screening tool designed against 50 oncogenes/tumor suppressor genes found in the COSMIC database. This panel has been developed as   View full product details >

General Specifications

Platform
Ion PGM™ System
Library Type
Targeted Sequencing Library
Workflow Step
Target Selection
Starting Material
Total RNA
Sequencing Type
Transcriptome Sequencing
Species
Human
Technique
Amplicon Sequencing
Product Size
24 reactions
Sample Type (Specific)
RNA (>500 bases)
Tissue (FFPE)
Starting Material (Amount)
500 pg of total RNA from fresh frozen tissue or 5 ng of RNA from FFPE samples
Regulatory Statement
For Research Use Only. Not for use in diagnostic procedures.

Product Applications

  • Cancer Research
  • Clinical
  • Gene Expression Analysis & Genotyping
  • Sequencing
4482572
d8682912115ccd149dbee97c21de7fe5_CmgtBuyProduct

LanthaScreen® ERK2 A375 Cell Line

See all Pathway Analysis Cell Based Assay Kits

Catalog # Unit Size List Price
K1798 1 vial 9880.00

Description

The Map Kinase (MapK) signal transduction cascade is activated by growth factors such as EGF, PDGF, and HGF. Binding of these factors to their respective cell surface receptors   View full product details >

General Specifications

System
LanthaScreen®
Readout
End Point
Cell Line
A375
Technique
TR-FRET
Cell State
Dividing Cells
Antagonists
Raf Inhibitor I
Gene Symbol
ERK2
Product Size
1 vial
Primary Agonist
Constitutive
Detection Method
Fluorescent
Druggable Target
Signaling Pathway
Kinases
Regulatory Statement
For Research Use Only. Not for use in diagnostic procedures.

Product Applications

  • Drug Discovery & Development
K1798
779ab5a0fd842eb63dcf966673549a89_CmgtBuyProduct

TaqMan® Genotyping Master Mix

See all SNP Genotyping Kits

Catalog # Unit Size List Price
4371355 1 x 10 mL 690.00

Description

The Applied Biosystems® TaqMan® Genotyping Master Mix is optimized for end-point fluorescence detection in SNP genotyping applications.

• Distinct clusters and   View full product details >

General Specifications

Platform
StepOne™, Standard Mode
7500 System
7000 System
StepOnePlus™, Standard Mode
7900HT System
7300 System
Technique
SNP Genotyping (Real-Time PCR-Based)
CNV (Copy Number Variation)
PCR Method
qPCR
Polymerase
AmpliTaq Gold® DNA Polymerase
Product Size
1 x 10 mL
Reaction Speed
Standard
Detection Method
Primer-Probe Detection
Genotyping Target
SNPs (Unknown or Numerous)
Drug Metabolizing Enzymes
SNPs (Known)
Copy Number Variants
Passive Reference Dye
ROX (Pre-mixed)
Sample Type (General)
DNA
Sample Type (Specific)
DNA (Genomic)
Purity or Quality Grade
UP (Ultra Pure)
Primer-Probe Compatibility
TaqMan®
Shipping Condition
Wet Ice
Regulatory Statement
For Research Use Only. Not for use in diagnostic procedures.

Product Applications

  • Drug Discovery & Development
  • Gene Expression Analysis & Genotyping
  • PCR & Real-Time PCR
4371355
b8570fa234555af71ac114b0472a0f79_CmgtBuyProduct