Tailored partnerships are built on a foundation of communication and understanding. Project goals are our first consideration and we have developed a dedicated infrastructure to design and manage these to a successful outcome.
For more information about our custom assay development services, please contact email@example.com.
Oncology Case Study
- Target generation—internal client challenges with target expression and purification were overcome using our portfolio of gene expression technologies and expertise in insect cell expression. Evaluation protein was delivered to client (5 weeks).
- HTS assay development—to support HTS and hit confirmation, our scientists developed a LanthaScreen® TR-FRET assay that met client performance criteria and delivered bulk HTS reagents (5 weeks).
- Secondary cellular assays—in parallel with the HTS campaign, we built a suite of cellular assays for lead optimization and SAR (WT target, disease variant, closest neighbor, and safety ortholog). Stable cell lines validated with reference compounds were delivered to the client (10 weeks).
- Secondary screening support—following identification of promising scaffolds, the client engaged with us to perform weekly medicinal chemistry screening support using the suite of developed cellular assays.
- Client technical hurdles resolved through partnership
- Tailored screening reagents delivered in less than 5 months
- Unique scaffolds identified from primary screen
- Medicinal chemistry activated
- Estimated client cost avoidance (FTE) = $1M