Analyze compound efficacy as full or partial agonists or antagonists using cell lines validated by the Life Technology team of Nuclear Receptor experts.  
Life Technology offers cell-based NR assays in two cell states:
Division Arrested, non-dividing cells, for “by the plate” assays Dividing Cells ideal for large screens.

See our validation data for a complete description of optimized assay conditions, DMSO tolerance, substrate loading time and pharmacology of know agonists and antagonists. See our customer protocol for a complete list of materials supplied and materials required but not supplied.  
If you do not see the target or assay format of your choice please contact us.

Request Assay Information        Use Assay Maker™

Search Assays alphabetically

Alphabetical List:
A - B - C - D - E - F - G - H - I - J - K - L - M - N - O - P - Q - R - S - T - U - V - W - X - Y - Z

 

Target and Alias(es) Accession Number Division Arrested Cat # Dividing Cells Cat # Validation Data Customer Protocol Available in
SelectScreen® Service
AR (AR/NR3C4) NP_036634   K1698
            X  
ER alpha (ERA/ESR1/NR3A1) NP_000116 K1393 K1688
            X
ER beta (ERB/ESR2/NR3A2) NP_001428 K1399 K1689B
            X
ERR alpha (ERR1/ESRRA/NR3B1) NP_004442 K1421 K1702
            X
FXR (NR1H4) NP_005114.1 K1397 K1691B
            X
GR (NR3C1) NP_000167 K1391 K1687
            X 
GR (NR3C1) Full length Endogenous GR
K1641B
            †
LXR alpha (LXRA/N41H3) NP_005684 K1401 K1692
            X
LXR beta (LXRB/NR1H2) NP_009052 K1415 K1699             X
MR (NR3C2)   K1409 K1696
            X
PPAR alpha
(PPARA/NR1C1)
NP_005027 K1875**
            †
PPAR delta (PPARD/NR1C2) NP_006229 K1395 K1690
            X
PPAR gamma (PPARG/NR1C3) NP_005028 K1419 K1701
            X
PR (PGR/NR3C3) NP_000917 K1403 K1693
            X
RAR alpha (RARA/NR1B1) NP_000955 K1387 K1685
            X
RAR beta (RARB/NR1B2) NP_000956 K1407 K1695
            X
RAR gamma (RARG/NR1B3) NP_000957 K1559 K1763
            X
RXR alpha (RXRA/NR2B1) NP_002948.1 K1411 K1697
            X
RXR beta (RXRB/NR2B2) NP_068811 K1405 K1694           X
TR alpha (THRA/NR1A1) NP_955366.1 K1385 K1684
            X
TR beta (THRB/NR1A2/T3RB)
NP_000452.2
K1389 K1686
              X
VDR (NR1I1) NP_000367 K1417 K1700
          X



*     K1641 - endogenous cell line using MMTV-bla HeLa cell background
**   K1875 - consumable cells, similar to division arrest cells, but transduced with BacMam reagent
†    Available for profiling through custom services, for more information contact discoveryservices@invitrogen.com