Select from among eight tools to locate off-the-shelf reagents or design your RNAi reagents for a particular gene target. 

siRNA for Cell Culture

siRNA Type Description Design Now
Silencer® Select siRNASilencer® Select siRNAs are the next generation of Ambion® siRNAs. These siRNAs incorporate the latest improvements in siRNA design, off-target effect prediction algorithms, and chemical modifications to yield siRNAs with excellent efficacy, potency, and specificity.order
Stealth RNAi™ siRNAStealth RNAi™ siRNA improves upon these traditional duplexes by using proprietary chemical modifications to help ensure better RNAi results. Stealth RNAi™ siRNA uses next-generation RNAi chemistry that allows for higher specificity and increased stability in serum and cell culture compared to standard siRNA.order
Unmodified Alexa Fluor® dye–labeled siRNATraditional unmodified siRNA duplexes synthesized on demand with the highest quality BLOCK-iT™ siRNAs.order
Unmodified/unlabeled siRNATraditional unmodified siRNA duplexes synthesized on demand with the highest quality Silencer® siRNAs.order

RNA interference (RNAi) is the best way to effectively knock down gene expression to study protein function in a wide range of cell types. Traditional RNAi methods for gene knockdown in mammalian cells involved the use of synthetic RNA duplexes consisting of two unmodified 21-mer oligonucleotides annealed together to form short/small interfering RNAs (siRNAs). Stealth RNAi™ siRNA and Silencer® Select siRNA improve upon these traditional duplexes by using proprietary chemical modifications to help ensure better RNAi results.

For Research Use Only. Not intended for animal or human therapeutic or diagnostic use.